Management Algorithm for Stroke Patient
Above is flow chart that show algorithm how to manage stroke patient. This flow chart is taken from www.phsa.ca.
Algorithm of Synergism of Hypertension and Hyperlipidemia in the Pathogenesis of Atherosclerosis.
Flow chart diagram shows us about mechanism of synergism of hypertension and hyperlipidemia in the pathogenesis of atherosclerosis. When hypertension accompanies hyperlipidemia, the two act together to trigger a cascade. Increased production of oxygen free radicals leads to increased transcription of redox-sensitive genes, which increases expression of vascular cell adhesion molecule-1 (VCAM-1) by the endothelium, resulting in increased recruitment of monocytes. Both hypertension and hyperlipidemia cause oxidative stress and oxygen free radical production by the arterial wall. By activating redox-sensitive transcriptional control mechanisms in the endothelium, a set of genes controlling monocyte recruitment into the arterial wall is activated. Atherosclerosis and foam cell formation occur only in the presence of hyperlipidemia. A synergistic reaction between hypertension and hyperlipidemia, causing or enhancing atherosclerosis, may occur because both states are associated with a common causal mechanism: induction of alterations in vascular redox state. mCSF indicates monocyte colony stimulating factor; MCP-1, monocyte chemotactic protein-1. Source: American Heart Association.